Precise quantification of tumor composition
As patient-derived xenograft (PDX), cell line-derived xenograft (CDX), patient-derived organoid xenograft (PDOX), and transplantable human tumor murine models play strong roles in preclinical cancer research, identifying how much of a sample is of human versus mouse origin can be key to revealing treatment-related results and choosing tumor fragments with the highest percentage of human tissue for cryopreservation and future passage.
By delivering breakthrough precision in measuring the composition of a mixed cellular population, IDEXX BioAnalytics' patent-pending ConfirmPDX(TM) assay provides an overview of the fractional abundance of human and murine cells within your tumor cells. Your team will always be armed with the data they need to make crucial study decisions.
Go far beyond “Yes” or “No”
Easy, one-step sample preparation and submission
ConfirmPDX is the first commercially available test for relative speciation of mixed population samples. And all you have to do is send in a single vial of cells, PDX tumor fragment, formalin-fixed paraffin-embedded tissue block, fresh-frozen tumor, or even whole blood (e.g., from a humanized mouse model animal). No advanced labeling is needed, and there’s no new sample preparation to learn. The data you need to drive your next steps confidently will be in your inbox at the speed you depend on from IDEXX BioAnalytics.
ConfirmPDX™ sample collection & shipping
Sample Requirements
Cells
1x106 cells/vial
In media, pellet or PBS
Tumor / Tissue
30 mg (2-3mm2)
Whole Blood
20 uL minimum volume
Collection Instructions
Submit one cryovial containing approximately 1x106 cells/vial of each biological or cultured cell sample.
If limited amounts of samples are available or require evaluation, call for more information.
Cells may be in the form of a pellet or in growth media, freeze media or phosphate buffered saline (PBS).
For liquid samples, submit one cryovial of each sample with 0.5 mL of sample/vial.
Shipping
Ship samples by overnight courier with sufficient ice packs or dry ice so that samples remain frozen during shipment
Turnaround Time
3-5 business days
Additional Information
The following tests can be performed on a single vial of cells: CellCheck, STAT-Myco, h-IMPACT, IMPACT, iCS-digital, STAT-Endo and ConfirmPDX.
A separate vial of cells is required for sterility testing
Please consult with your account manager if you have any questions