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      Pharmacokinetics

      Advanced LC-MS/MS Bioanalysis for Small Molecules

       

       

      DMPK - 700x400

      Cutting-edge LC-MS/MS Bioanalysis for Small Molecule Compounds

      Count on us to deliver with unmatched speed, precision, and adaptability.IDEXX BioAnalytics provides high-quality and flexible LC-MS/MS bioanalysis for small molecule compounds with a fast turnaround. In addition to standard protein precipitation, we offer solid phase extraction and solid-supported liquid extraction. We offer the same high-quality, flexible, and fast turnaround in our bioanalysis laboratory as we do for our current clinical and anatomic pathology services.

      Rely on our swift, accurate, and versatile approach to exceed your needs.

      Extraction Types

      • Protein precipitation
            – Organic and acidic methods
      • Solid Phase Extraction
      • Solid Supported Liquid Extraction

      Sample Types 

      • Blood
      • Serum
      • Urine
      • Tissue homogenates

      Analytical Equipment

      • Sciex 5500+ Triple Quadrupole Mass Spectrometer
      • ESI source and APCI source
      • Shimadzu Nexera X2 HPLC
      • Integra Biosciences VIAFLO96 pipetting robot
      • Beckman Avanti JXN-26 refrigerated centrifuge
      • Mettler XPR36DR analytical balance
      • Biotage TurboVap96 evaporator
      • WinNonlin Phoenix software

      Bioanalytical Services: Small molecule LC-MS/MS Services

      Method Feasibility

      •  Compound Detection
        • Compound infusion
        • Ionization parameter optimization
      • UHPLC column elution
        • Column and mobile phase selection
        • Compound injection for retention time and peak shape assessment

      Development and Pre-qualification

      • Accuracy determined at 3 concentrations
      • Precision determined at 3 concentrations
      • Linearity determined at 8 concentrations
      • Limit of Detection identified
      • Quality control run with every 10 samples

      Method Qualification

      Sensitivity and Linearity

      • Assessment of duplicate extracted and non-extracted standard curves for linearity and sensitivity and reproducibility on two or three different injection days

      Quality Controls

      • High, medium, and low concentrations in duplicate
      Small Molecule BioAnalysis 700x400

      Non-GLP Sample Analysis

      • Pre- and post-analysis standard curves for QC

      • Interspersed QCs through samples

        • 10% of total number of samples tested

      • Summary report in Excel format

        • System suitability 

        • Standards & QC: Reporting of used/excluded, nominal, back calculated, accuracy, coefficient of variation

        • Carryover

        • Samples: Calculated concentration in tabular format, graphical format optional

      Fast, accurate, and reliable results from the team you know and trust.

      Connect with IDEXX BioAnalytics today.